PHS 621 - Introduction to Pharmaceutical Manufacturing Processes

This course explores: (a) Regulation of drug products and biopharmaceutics, application of kinetics to stability, dissolution, absorption, and other biopharmaecutical processes, and bioavailability and generic equivalence; (b) Solid and solution dosage forms and pharmaceutical calculations. Physicochemical properties of drug molecules and their effect on formulation, manufacturing, and administration of solid and solution products will be emphasized. Additionally, pharmaceutical calculations and pharmacy compounding techniques will be introduced. Other topics include particle engineering, wet granulation, high shear granulation, fluidized bed technology, direct compression, spray drying, freeze drying, melt extrusion, disperse systems, sterilization, pharmaceutical test methods including different dissolution test methods, HPLC and other commonly used test methods, process validation and quality control. Students will not only learn state-of-the-art pharmaceutical processing technologies and underlying chemical engineering principles, but also be exposed to current challenges in the pharmaceutical manufacturing field and possible solutions. The course will prepare students for pharmaceutical manufacturing and R&D jobs. (Offered as needed.) 3 credits